Everything we know About Novocaine (2025) film: Jack Quaid Stars in Action-Packed Thriller

The final trailer for Novocaine has just dropped, giving fans an even closer look at this thrilling action-comedy. The movie, starring The Boys' Jack Quaid, promises a unique twist on the classic action hero with Quaid’s character, Nathan Caine, embarking on a high-stakes rescue mission while navigating a dangerous underworld. 

The latest footage showcases intense action sequences and moments of unexpected humor, teasing a gripping ride from start to finish. Novocaine joins a wave of action films in 2025 where the hero isn't your typical muscle-bound action star. With movies like Nobody 2 and Love Hurts following a similar tone, Novocaine stands out with its blend of comedic elements and hard-hitting action.

The anticipation for Novocaine is mounting as the premiere approaches. Get ready for a one-of-a-kind action-packed adventure that’s sure to keep you on the edge of your seat. Stay tuned for more details as the film's release draws closer! We’ll keep updating this page with all the latest news and surprises about the film.

Release date & Where to Watch

Novocaine hits US theaters on Friday, March 14, 2025, followed by its UK release on Friday, March 28, 2025, and Australia on Thursday, April 3, 2025. The film is rated R for intense violence, graphic imagery, and strong language. 

Distributed by Paramount Pictures, it will likely stream on Paramount+ after its theatrical run, with additional availability for rent or purchase on other platforms.

What is the plot of Novocaine (2025) film?

In Novocaine, Nathan Caine, a mild-mannered bank executive, lives with a rare condition called congenital insensitivity to pain (CIP), which makes him unable to feel physical pain. When his girlfriend, Sherry, is kidnapped during a bank robbery, Nathan becomes an unlikely hero. 

His unique condition, earning him the nickname "Novocaine," allows him to endure extreme situations while he fights to rescue her. As he faces a group of armed robbers and a dangerous underworld, Nathan must use his inability to feel pain to navigate the perilous journey and save the woman he loves.

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Who’s Starring in Novocaine?

• Jack Quaid (The Boys, Companion) as Nathan "Nate" Caine,  a sheltered bank executive who has a condition where he does not feel pain. 

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• Amber Midthunder (Prey) as Sherry Margrave, Nathan’s kidnapped girlfriend.
• Ray Nicholson (Smile 2) as Simon Greenly, a bank robber who admires Nathan and becomes entangled in the heist.
• Betty Gabriel (Jack Ryan) as Mincy Langston, an officer of the SDPD
• Matt Walsh (Manhunt) as Coltraine Duffy, an officer of the SDPD
• Lou Beatty Jr. (A Million Little Things) as Earl
• Evan Hengst (The Kissing Booth 3) as Ben
• Conrad Kemp (Rust Road) as Andre
• Jacob Batalon (Spider-Man movies) as Roscoe Dixon, Nathan's online gaming friend who provides tech-savvy assistance during the rescue mission.
• Craig Jackson as Nigel
• Garth Collins as Zeno
• Tristan de Beer as Asshole
• Jessica Leigh Stanley as Waitress
• Chioma Antoinette Umeala as Bartender
• Margot Wood as Elderly Woman
• Dylan Skews as Officer 1
• Keeno Lee Hector as Downed Officer
• Maria Vos as Call Trace Officer

Is There a Trailer for Novocaine?

In the official trailer for Novocaine, we meet Nathan Caine, a man born with a rare genetic disorder that renders him impervious to physical pain. This unique condition is highlighted when Nathan's friend remarks, "You don't feel pain."

Nathan's extraordinary ability becomes central when his new girlfriend, portrayed by Amber Midthunder, is kidnapped during a bank robbery. Determined to rescue her, Nathan confronts the criminals, leading to intense action. The trailer builds anticipation with the tagline, "He doesn't feel any pain."

For a closer look, you can watch the official trailer here:

The final trailer for Novocaine offers a gripping glimpse into the film's high-stakes narrative. The trailer opens with Nathan Caine (Jack Quaid) in a tense confrontation, stating, "I'm not afraid of pain." This sets the tone for the ensuing chaos, as Caine's unique condition—his inability to feel pain—becomes both a curse and a weapon. 

For a visual experience, you can watch the final trailer here:

Novocaine also aired a TV spot during the Super Bowl on Feb. 9, 2025. Watch the exclusive Big Game spot here: Nathan Caine can’t afford to fumble this.

Filming Details

Filming for Novocaine started on April 8, 2024, in Cape Town, South Africa. The film is financed by Domain Entertainment.

Behind the Scenes

Dan Berk and Robert Olsen, co-directors of Novocaine, have collaborated on multiple projects, including Body, The Stakelander, Villains, and Significant Other. However, Novocaine marks their most ambitious project yet.

Written by Lars Jacobson, the film is a joint production between Safehouse Pictures, Circle Management + Production, and Infrared Pictures. Novocaine is also the first film under FilmNation Entertainment's Infrared label. In February 2024, Paramount Pictures acquired the film.